In 2006, Jo Soo Min officially debuted as an actress in the historic drama, "Seoul 1945". In the same year, she acted in the comedic family drama "Famous Princesses" and the inspirational romantic drama "The Invisible Man, Choi Jang-soo". In 2019, Soo-min was cast in tvN's romantic drama "Touch Your Heart", which was also her first drama after her comeback. She also announced that she signed a contract with Awesome ENT. In that same year, she played the lead role in KBS's special drama "Birthday Letter" and won the KBS Best Actress in a One-Act/Special/Short Drama award for her performance.